Tanovea approved by FDA in 2017
Tanovea® for the treatment of lymphoma in dogs
Tanovea is an exciting new chemotherapy drug for lymphoma, which became conditionally approved by the FDA in 2017. Tanovea-CA1 (rabacfosadine) works as a nucleotide analogue, and is the first new animal drug intended to treat canine lymphoma. In previous clinical studies, Tanovea has been shown to be highly effective with a 77% overall response rate. Tanovea was generally well-tolerated and demonstrated high rates of response in both dogs naïve to previous treatments as well as in dogs that relapsed or failed previous chemotherapy. Tanovea is administered IV on a 3 week schedule. The most common side effects seen in dogs treated with Tanovea-CA1 include decreased white blood cell count, diarrhea, vomiting, decreased or loss of appetite, weight loss, decreased activity level, and skin problems (hair loss, sores, and scabs). Rarely pulmonary fibrosis, hyperbilirubinemia, and proteinuria have also been reported. We are currently primarily using Tanovea in the rescue setting, although large scale studies are ongoing and recommendations may change in the future.